|Supercritical Fluid Chromatography - Mass Spectrometry: Robust, Reliable and Required
|Exploiting Separation Science
|Prof John Langley
|University of Southampton
Abstract Information :
SFC now delivers on the chromatographic promises with robust and reliable instrument platforms. The solvation power, selectivity and peak capacity of modern Ultrahigh Performance Supercritical Fluid Chromatography (UHPSFC) coupled with mass spectrometry affords the ideal analytical platform to address classes of compounds that were previously a challenge for GC-MS and RP-UHPLC-MS approaches.
UHPSFC, in the form of Ultra Performance Convergence Chromatography (UPC2) has been integral to Southampton Chemistry open access (walk-up and use) chromatography mass spectrometry facility since 2013 where it complements existing liquid chromatography and gas chromatography options (HPLC-MS (ESI/APCI), GC-MS (EI/CI) to afford a comprehensive, modern and fast separation science and mass spectrometry option to address the wide range of diverse and challenging chemistries.
The extended capability and complementarity of SFC delivers unique solutions across a broad range of application areas, e.g. synthetic organics, pharmaceuticals, petrochemistry, lipids, nucleotides and its impact in many other research areas will be discussed.