HTC-15 - Abstract

Abstract Title: Separation science and its use for generating data, information and understanding
Abstract Type: Seminar
Session Choice: Other
Presenter Name: Prof Hans-Gerd Janssen
Co-authors:Mr Boudewijn Hollebrands
Company/Organisation: Unilever Research and University of Amsterdam
Country: Netherlands

Abstract Information :

Separation methods generate data, or numbers. Sometimes these numbers are the aim of the analysis, but very often they are just the start of generating information, or ultimately knowledge and understanding. In the last two decades we have significantly improved our ability to obtain more data, more reliable data, cheaper and faster. Techniques that enable us to do so include comprehensive chromatography, hyphenated sample preparation methods, high resolution accurate mass MS etc. Due to these improvements the generation of data is hence no longer the bottleneck. The problem now is getting all relevant information out of the enormous amounts of data we generated. New data treatment and processing methods are needed. But we should also approach our problems in a cleverer manner. Not just try to generate as much data as possible, but try to obtain structured data, group separations, data related to effects, etc. In the presentation new methods of generating more data will be discussed. These include comprehensive GCxGC, LCxGC, high resolution MS, MS/MS etc. But specifically we will also show that sometimes 'less is more'. Selective derivatisation strategies will be used to monitor specific classes of compounds only, normal phase LC will be shown to provide selectivity rather than just huge peak numbers, and finally some simple yet clever data processing methods will be demonstrated.