HTC-15 - Abstract

Abstract Title: Kinetics and mass transfer phenomena in modern chiral stationary phases
Abstract Type: Seminar
Session Choice: Fundamentals in Separation Science (KVCV)
Presenter Name: Alberto Cavazzini
Co-authors: Martina Catani
Omar H Ismail
Francesco Gasparrini
Company/Organisation: University of Ferrara
Country: Italy

Abstract Information :

In the last decades, several examples of chiral stationary phases (CSPs) prepared on particles (both fully porous and pellicular) suitable for high efficient, ultrafast enantioseparations have been presented. These phases have been successfully employed to perform sub-second separations of several classes of enantiomers.

Contrary to what happened in achiral reversed phase separations especially on C18 columns, however, the fundamentals of mass transfer phenomena on modern CSPs have been barely studied. In this work, state-of-art techniques have been employed to study mass transfer in modern CSPs. To this scope, different kinds of CSPs have been considered including teicoplanin-based and Whelk O1 CSPs. Teicoplanin-based SPPs of 2.6 and 2.0 µm particle diameter and Whelk-O1 FPPs of 2.5 and 1.9 µm were employed in our study.

The results of this investigation reveal some unexpected facts. In particular, they oppose the idea of the supposed superiority of chiral SPPs over their fully porous counterparts to achieve high efficient, ultrafast enantioseparations.