HTC-15 - Abstract

Abstract Title: Flow Modulated Two-dimensional Gas Chromatography Coupled to Tandem Mass Spectrometry for “Comprehensive” characterization of Complex Samples
Abstract Type: Seminar
Session Choice: Comprehensive Chromatography - The State of the Art
Presenter Name: Prof Luigi Mondello
Company/Organisation: University of Messina
Country: Italy

Abstract Information :

The search for more powerful and discriminating analytical techniques has grown exponentially over the last decade, to address the high complexity of many natural and synthetic samples, and the increased demands for specificity of information required. To achieve the desired level of accuracy and reliability of analytical data, the analysis of complex matrices requires the combination of both powerful separation techniques and sensitive detection.

A number of advantages are to be gained by coupling two-dimensional comprehensive chromatography (GCxGC) to Mass Spectrometry (MS): handle complex samples, reduce matrix complexity, detect trace or ultra-trace compounds, increase confidence in structure assignment and quantitative results. The hyphenation to triple quadrupole MS affords extremely high-resolution, as well as targeted and untargeted analysis; in the multiple reaction monitoring (MRM) mode selectivity is enhanced, sample consumption reduced, and also the need for tedious clean-up procedures.

The advantages of using a flow-modulation device in GCxGC will be also illustrated over the cryogenic one, consisting in the compatibility with virtually any detectors and flow rates, reduced costs and environmental risks.

A series of flow-modulated GCxGC-MS applications will be shown, relative to a variety of complex real-world samples.