HTC-15 - Abstract

Abstract Title: Direct infusion MS – who needs hyphenation anyway?
Abstract Type: Seminar
Presenter Name: Dr Sam Whitmarsh
Co-authors:Dr Chrissie Wicking
Company/Organisation: BP
Session Choice: Analysis of Complex Energy Products

Abstract Information :

It is not hyperbole to say that benchtop, high resolution mass spectrometry (MS) has revolutionised analytical science over the past 20 years and changed what we understand of our world. Direct infusion experiments have existed since the very first mass spectrometers but hyphenation with liquid or gas chromatography has been the dominant application of these instruments over most of that time. The advance of ambient MS techniques and the requirement to reduce analysis times for large data sets - particularly in the omics fields has seen the proportion of direct infusion experiments increase. As MS instruments improve there is perhaps a tendency to view chromatography as old technology that is too slow and awkward to be part of a modern workflow.

This presentation looks at both the advantages and disadvantages of direct infusion mass spectrometry and hyphenated techniques through the lens of the study of complex mixtures such as crude oil and its derivatives. Examples from both the upstream and downstream will be discussed using different atmospheric pressure ionisation, ambient ionisation, and field ionisation MS techniques along with hyphenation to field asymmetric ion mobility spectrometry (FAIMS), liquid chromatography and gas chromatography.