|Development of a Novel Immobilised Polysaccharide Chiral Stationary Phase for Enantiomeric Separations
|Fundamentals in Separation Science (KVCV)
|Dr Daniel Eßer
|Mr Masahide Kobayashi
Mr Toshikazu Adachi
Dr Takehiro Iwadate
Mr Tsuyoshi Watabe
Dr Noritaka Kuroda
|YMC Europe GmbH
Abstract Information :
The role of enantioseparation is becoming more and more important especially in the pharmaceutical industry. It is known that some enantiomers of racemic drugs show great differences in biological activities such as pharmacology, toxicology, pharmacokinetics, and metabolism. Nowadays, many single-enantiomer drugs are marketed, and the demands on enantiopurity determinations and enantiopurification are increasing.
Silica gel coated or immobilised with polysaccharides are known to be useful for separation of a wide range of racemic compounds. Among these 2 types, immobilised chiral stationary phase (CSP) columns are now common for measuring optical purity, and offer advantages when analysing and isolating chiral materials. YMC has developed a novel immobilised type CSP (named "CHIRAL ART Cellulose-SJ"), a cellulose tris(4-methylbenzoate) derivative immobilised on silica particles.
In this poster, characteristics of this new CSP column will be shown, and some examples of efficient method screening for separation of racemic compounds.