| Abstract Title: | Routine Determination of Per- and Polyfluoronated Alkyl Substances (PFAS) in Drinking Water by Direct Injection Using UPLC-MS/MS to Meet the EU Drinking Water Directive 2020/2184 Requirements |
| Presenter Name: | Mr Janitha De Alwis |
| Company/Organisation: | Waters Corporation |
| Country: | United Kingdom |
Abstract Information :
Abstract, rnThe purpose of this work is to demonstrate a direct injection UPLC-MS/MS method for the determination of PFAS compounds in drinking water in response to the parametric level requirements in the 2020 recast EU Drinking Water Directive.1 The method performance study was completed on an ACQUITY UPLC I-Class PLUSTM System with a Xevo TQ-XSTM and UniSprayTM ion source. Samples were prepared by dilution with an acidified organic solution containing internal standard directly into an autosampler vial.rnA method validation study was carried out on 3 common drinking water matrices; tap water from known soft and hardwater areas and bottled mineral water. The method performance was assessed using 3 spike levels at 2, 10, and 100 ng/L (1.2, 6, and 60 ng/L in vial concentration) for all analytes, with 7 replicates at each level. Twelve analytes were corrected using internal standards with no suitable internal standard for PFPS, PFHpS, PFNS, PFTrDA, PFDS, PFUnDS, PFDoDS, and PFTrDS. Average method performance for trueness was 89 to 112% across all matrices. RSDs were all at or below 14%.rnAll calibration graphs had residuals within 20% and R2 values of 0.99 or higher with linear regression fit. Retention time stability across all the method validation study batches for all analytes was below RSD 3.2%.rn1. Directive (EU) 2020/2184 of the European Parliament and of the Council of 16 December 2020 on the Quality of Water Intended for Human Consumption (Recast) [Online] https://eur-lex.europa.eu/eli/dir/2020/2184/oj.rn rn© 2022 Waters Corporationrn
