SinS - Abstract

Abstract Information :

In the Separation Science Laboratory at AstraZeneca a broad range of potential drug candidates are accommodated in three different workflows, with the largest portion of them passing through the Plate Purification stream. The Plate Purification work stream has been optimized to provide an environment with short delivery cycle times in combination with a lot of walk-away time for the scientists. This have been achieved through a combination of hardware systems, a clever quantification method and one software tracking all samples and providing output to various purification and liquid handling systems. Nonetheless, the field of chemistry is rapidly changing and in order to accommodate a larger amount of samples with increasingly challenging needs we continuously work to improve our work environment and daily delivery. Herein, three different digitalisation measures we have taken to improve our workflows are described. (I) We have approached the need for less interruptions and more walk-away time for the scientists by developing a model for automated solubility assessment using computer vision. This will be exemplified by post evaporation solubilisation and pooling of purified compounds using a Tecan Evo liquid handler. (II) Another time consuming task is the evaluation of analytical data, both for choosing a suitable scale up method and for quality control. By the utilisation of the tool MGears these processes can be done automatically and, additionally, the software can evaluate system performance. (III) The last piece is the implementation of the user-centric software Atheer which allows scientists to have access to updated work instructions, log sheets and error reporting on any app based device allowing us to move towards being a paperless laboratory supporting the AstraZeneca sustainability goals.